June 29, 2022

Calyxt announces that the BioFactory ™ pilot production system is now operational | Business and finance

ROSEVILLE, Minnesota, Jan.6, 2022 / PRNewswire / – Calyxt, Inc. (Nasdaq: CLXT), a plant-based synthetic biotechnology company, today announced that its BioFactory ™ pilot production system, installed in late December 2021 , is now operational at its head office in Minnesota.

“I am proud of the efforts made by our team and our suppliers to reach this milestone on time, as it marks an important step in the evolution of our production. The data we collect and analyze will guide future decisions and help improve our testing cycles. and the development schedule, ”said Michael A. Carr, President and CEO of Calyxt. “We are encouraged by the number of entries from potential customers regarding our technology and the quality of our conversations. We are seeking customer orders of two to four compounds for development by the end of 2022, and therefore we use our selection criteria to determine which compounds to look for based on customer needs. We look forward to providing further updates on our continued evolution and customer acquisition throughout the year. “

On October 5, 2021, Calyxt announced the launch of a strategic initiative that has focused the Company on engineering synthetic biology solutions for a diverse customer base using its extensive proprietary PlantSpring ™ technology platform. PlantSpring’s output is integrated with the company’s BioFactory production system, allowing Calyxt to rapidly prototype and produce complex plant-derived compounds without the need for outdoor growing systems.

Calyxt’s proprietary Plant Cell Matrix ™ systems have been placed in the BioFactory, where they will be used for pilot scale testing. The pilot is currently in its testing period, during which the Company will ensure that the system, including its data generation and communication capabilities for artificial intelligence modeling, perform as expected. This is a key step in understanding the scalability of the BioFactory production system.

About the PlantSpring ™ technology platform and the BioFactory ™ production system Calyxt’s technology platform, PlantSpring, is founded on over a decade of experience in engineering plant metabolism and comprises its knowledge scientists, its proprietary systems, tools and technologies; and a growing set of AIML capabilities. This licensed platform offers innovation through an efficient development process. The process includes identifying breakthrough compounds based on customer needs, designing strategies to reprogram host cells, engineering plant cell metabolism to optimally produce targeted plant-based chemistries, and production of these target chemistries on a laboratory scale. Calyxt has developed early stage AIML capabilities in PlantSpring, which enable learning and adaptation of knowledge gained from past activities and can be combined with predictive analytics to rapidly prototype and provide feedback, speeding up the time needed to complete the design-engineer-check development cycle and help mitigate the risk associated with commercial scale-up. As a result, Calyxt believes it can develop biomolecules in plants for its customers at faster rates than its competitors in the synthetic biology industry. The release of the PlantSpring platform integrates with the company’s newly commissioned BioFactory production system.

The BioFactory production system is the culmination of the work of Calyxt researchers and will allow the company to expand its production methods from outdoor-only farming systems to also include production systems based on bioreactors at controlled environment. The BioFactory harnesses the potential of plant cells in a multicellular matrix structure and uses nutrient media for its production. The BioFactory exploits multiple cell types and the multicellular matrix structures allow the processing of plant-based chemistries of increased complexity compared to those possible using traditional fermentation systems or single-cell plant culture methods. In addition, the rate of growth of the matrix over time should accelerate the production of the compound on a large scale. As a result, Calyxt’s production system is able to unleash the power of plants to produce complex compounds that are finite, difficult to source sustainably, and which may not be able to be produced using other production methods. Calyxt has been operating lab-scale bioreactors for several months and its first pilot-scale bioreactor has been commissioned and is expected to be online by the end of 2021. There may be a range of vessel sizes. between the initial pilot installation and commercial production. For the transition from pilot to commercialization, the Company’s current plan is to use third parties, known as infrastructure partners, for the large-scale production of BioFactory. Due to its production methodology, Calyxt believes the BioFactory has the potential to be one of the most sustainable production systems in all industries.

About Calyxt: Calyxt (Nasdaq: CLXT) is a synthetic, plant-based biotechnology company. The company leverages its proprietary PlantSpring ™ technology platform to design innovative materials and products for its customers to help them achieve their sustainability goals. Calyxt’s diversified offerings are mainly supplied through its exclusive BioFactory ™ production system. For more information, visit www.calyxt.com.

PlantSpring, BioFactory, Plant Cell Matrix, and the Calyxt logo are trademarks of Calyxt, Inc. All other marks are the property of their respective owners.

Forward-looking statements: This press release contains “forward-looking statements” within the meaning of the safe harbor provisions of the United States Private Securities Litigation Reform Act of 1995. In some cases, you may identify such statements by forward-looking words such as ” anticipates “,” believes “,” continues “,” considers “,” expects “,” intends “,” could “,,” “will”, or the negative of these and other terms Similar terms. Forward-looking statements in this press release include statements about Calyxt’s pipeline and product development; Calyxt’s ability to use the BioFactory to design precursor molecules and convert them to broader chemistries requested by customers potentials; Calyxt’s ability to achieve larger scale production and performance of target molecules; and commercial demand for Calyxt’s synthetic biology solutions. These and other forward-looking statements are predictions and projections of future events and trends based on Calyxt’s current expectations, goals and intentions and are based on current assumptions. The actual results, level of activity, performance or achievements of Calyxt could be materially different from those expressed, implied or anticipated by forward-looking statements due to various factors, including, but not limited to: impact of increased competition, including competition from a wider range of synthetic biology companies; disruptions at Calyxt’s key facilities, including disruptions affecting its BioFactory production system; changes in customer preferences and market acceptance of Calyxt’s products; competition for customers, partners and licensees and the proper execution of development and license agreements; the impact of adverse events during development, including unsuccessful pilot production of compounds or the generation of inconsistent data; disruptions to supply chains, including raw material inputs for Calyxt’s BioFactory; the impact of changes or increases in supervision and regulation; intellectual property disputes or disputes; the proliferation and continuous evolution of new technologies; and other material factors discussed under the heading “Risk Factors” in Calyxt’s Annual Report on Form 10-K and subsequent filings on Form 10-Q or Form 8-K with the Securities and Exchange United States Commission. All forward-looking statements made by Calyxt management are based solely on information currently available to them and speak only as of the date on which such statement is made. Calyxt assumes no obligation to publicly provide revisions or updates to any forward-looking statement, whether as a result of new information, future developments or otherwise, if circumstances change, except as otherwise required by law. .

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